Queen’s Romford

Consultant Academic Lead: Nik Haliasos

Trainee Academic Lead: Ciaran Hill

The Royal London

Consultant Academic Lead: Chris Uff

 

Below is a list of all clinical trials to which we are recruiting patients  at Queen’s and The Royal London.

A list of ongoing clinical audit and service evaluation studies can be found on our clinical governance page.

 

Clinical Trial Recruitment

UCES

Understanding Cauda Equina Syndrome

The British Neurosurgical Trainee Research Collaborative is starting recruitment for a national multicentre observational cohort study on ‘Understanding Cauda Equina Syndrome’. Recruitment starts on 1st June 2018 and runs for one year until 31st May 2019.

 

TOPSAT 2

Treatment of Poor Grade Subarachnoid Haemorrhage Trial 2

The aim of this study is to establish the efficacy of a strategy of early aneurysm treatment (within 72h of ictus) in a population of World Federation of Neurosurgical Societies grade 4-5 (high grade) aneurysmal subarachnoid haemorrhage (aSAH) patients in comparison with the conventional strategy of treatment of aneurysm after neurological improvement (to WFNS grade 1-3).

 

SFX01

SFX 01 after Subarachnoid Haemorrhage

Sulforaphane is a substance that is released when broccoli is eaten. It has been studied extensively in the laboratory and has been shown to improve outcome after SAH in animals. However on its own SFN has a short shelf life and is not practical for clinical use. When synthetic SFN is mixed with cyclodextrin it forms SFX-01. SFX-01 is stable and on ingestion releases SFN.

This study will assess if SFX-01 is safe, gets into the brain and reduces the inflammation after SAH.It will randomise 90 patients who have suffered a severe SAH in the last 48 hours to receive either SFX-01 or placebo tablets for 28 days. They will be monitored closely with blood and cerebrospinal fluid samples and ultrasound recordings while in hospital and will be followed up at 28 days, 3 months and 6 months with assessments of their outcome. They will also have an MRI at 6 months. By the end of this study we will have assessed the safety and tolerability of SFX-01, established how much and how quickly it gets into the brain and have an estimate of how much of a difference it makes to patient outcome. This will allow us to design a future study to definitively ascertain is usefulness in SAH patients

 

DEX CSDH

DEXamethasone in Chronic SubDural Haematoma

A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematoma

 

PRESTO

PRESTO Pragmatic Randomised Evaluation of Stable Thoracolumbar fracture treatment Outcomes

Feasibility study, surgical fixation vs conservative management of relatively stable thoracolumbar fractures. Recently opened

The PRESTO study is a multicentre, pragmatic randomised controlled feasibility trial that aims to establish whether it is possible to deliver a trial comparing surgical fixation to initial non-operative management for adult patients with a relatively stable thoracolumbar fracture without spinal cord injury.

 

RESCUE-ASDH

Randomised Evaluation of Surgery with Craniectomy for patients Undergoing Evacuation of Acute SubDural Haematoma

RESCUE-ASDH is a multi-centre, pragmatic, parallel group randomised trial that aims to compare the clinical and cost-effectiveness of decompressive craniectomy versus craniotomy for the management of adult head-injured patients undergoing evacuation of an acute subdural haematoma (ASDH).

 

ROAM Trial

Radiation versus Observation following surgical resection of Atypical Meningioma: a randomised controlled trial (The ROAM trial)

ROAM is a multi-centre, randomised controlled trial. The trial will randomise patients who have undergone gross total surgical resection of atypical (grade II) meningioma to receive either early adjuvant fractionated radiotherapy for 6 weeks (intervention) or active monitoring (comparator).

 

TCP

Transitional Care Programme

Transitional care programmes are becoming increasingly recognised for their ability to promote safe and timely transfer of patients from the vulnerable stage between the inpatient hospital stay to subsequent care settings. They intend to improve both healthcare quality and safety (Robertson et al, 2017)

Here, at Barts Health, we are conducting a transitional care intervention with enhanced nurse-led care coordination, patient education sessions, improvements in communication between hospital and general practitioner providers, and follow-up phone calls.